Saldana's breakthrough came in 2009 with the roles of Nyota Uhura in Star Trek and Neytiri in James Cameron's Avatar (2009).
The latter film received widespread acclaim, and is the highest-grossing film of all time.
To combat the effects of this disease, Saldana said she and her husband adhere to a gluten- and dairy-free diet.
'Let me tell you something, it will never be the right time for anybody in your life that you get pregnant,' she told USA Today.
In 2004 she also made appearances in Haven and Temptation, both of which had little to no box office success.
In 2005, Saldana appeared in Constellation, Guess Who with Ashton Kutcher, and Dirty Deeds. Abrams asked Saldana to play the role because he had seen and liked her previous work.
The film depicts the late singer's rise to fame and relationship with her manager Clifton Henderson.Gibbs for a chance to confront Jack Sparrow for stealing her ship.As to why she never appeared in any further films in the franchise, Saldana revealed that she almost quit acting following "disrespectful treatment" on set of the film.Simone's family has been critical of the decision to cast her in the role.In July 2016, during an interview with Net-a-Porter's The Edit, Saldana revealed that she has Hashimoto's thyroiditis, an autoimmune disease, along with her mother and sisters.
In 2013, Saldana reprised her role as Uhura in Star Trek Into Darkness, the sequel to the 2009 Star Trek.